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Periostin in inflammation and allergy

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Abstract

We found for the first time that IL-4 and IL-13, signature type 2 cytokines, are able to induce periostin expression. We and others have subsequently shown that periostin is highly expressed in chronic inflammatory diseases―asthma, atopic dermatitis, eosinophilc chronic sinusitis/chronic rhinosinusitis with nasal polyp, and allergic conjunctivitis—and that periostin plays important roles in the pathogenesis of these diseases. The epithelial/mesenchymal interaction via periostin is important for the onset of allergic inflammation, in which periostin derived from fibroblasts acts on epithelial cells or fibroblasts, activating their NF-κB. Moreover, the immune cell/non-immune cell interaction via periostin may be also involved. Now the significance of periostin has been expanded into other inflammatory or fibrotic diseases such as scleroderma and pulmonary fibrosis. The cross-talk of periostin with TGF-β or pro-inflammatory cytokines is important for the underlying mechanism of these diseases. Because of its pathogenic importance and broad expression, diagnostics or therapeutic drugs can be potentially developed to target periostin as a means of treating these diseases.

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Acknowledgements

We thank Dr. Dovie R. Wylie for the critical review of this manuscript. We also thank the colleagues and collaborators as follows for contributing to the present work: Go Takayama, Masaru Uchida, Miho Masuoka, Hiroshi Shiraishi, Minako Ontsuka, Kazuto Taniguchi, Kazuhiko Arima, Shoichi Suzuki, Shoichiro Ohta, Go Kato, Koichiro Takahashi, Shin-ichiro Hayashi (Saga Medical School), Noriko Yuyama (Genox Research, Inc.), Akihiro Ishida, Nobuo Ohta (Yamagata University), Takahiro Ninomiya, Shigeharu Fujieda (Fukui University), Hiroshi Fujishima (Tsurumi University), Naoko Okada, Kenji Matsumoto (National Research Institute for Child Health and Development Laboratory), Yuzaburo Inoue, Naoki Shimojo (Chiba University), Yoshihiro Kanemitsu, Tadao Nagasaki, Tomoko Tajiri, Hisako Matsumoto (Kyoto University), Masako Matsuzaka, Koichi Fukunaga (Keio University), Koichiro Asano (Tokai University), Yorihisa Kotobuki, Ichiro Katayama (Osaka University), Kenzen Kou, Yukie Yamaguchi, Michiko Aihara (Yokohama City University), Timothy Hinks, Peter Howarth (Southampton University Hospital), Mi-Ae Kim, Hae-Sim Park (Ajou University), Anna James, Sven-Erik Dahlen (Karolinska Institutet), Ayami Kamei, Masayuki Takai, Yoshinori Azuma (Shino-Test Co.), Simon J. Conway (Indiana University), Masaki Okamoto, Tomoaki Hoshino, Kiminori Fujimoto (Kurume University), Naoko Kushima, Hiroshi Ishii, Junichi Kadota (Oita University), Hiroshi Yamamoto, Masayuki Hanaoka (Shinshu University), Noriho Sakamoto, Shigeru Kohno (Nagasaki University), Keiichi Akasaka, Hironori Sagara (Dokkyo Medical University Koshigaya Hospital), and Takeshi Johkoh (Kinki Central Hospital of Mutual Aid Association of Public Teachers).

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Correspondence to Kenji Izuhara.

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Izuhara, K., Nunomura, S., Nanri, Y. et al. Periostin in inflammation and allergy. Cell. Mol. Life Sci. 74, 4293–4303 (2017). https://doi.org/10.1007/s00018-017-2648-0

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