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Introductory review: periostin—gene and protein structure

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Abstract

Although many studies have described the role of periostin in various diseases, the function of the periostin protein structures derived from alternative splicing and proteinase cleavage at the C-terminal remain unknown. Further experiments revealing the protein structures that are highly related to diseases are essential to understand the function of periostin in depth, which would accelerate its clinical application by establishing new approaches for curing intractable diseases. Furthermore, this understanding would enhance our knowledge of novel functions of periostin related to stemness and response to mechanical stress.

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Acknowledgements

I thank my collaborators involved in the periostin project for providing figures.

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  1. International Frontier, Tokyo Institute of Technology, S3-8, 2-12-1 Oookayama, Meguro-ku, Tokyo, 152-8550, Japan

    Akira Kudo

  2. Department of Pharmacology, School of Dentistry, Showa University, Tokyo, 142-8555, Japan

    Akira Kudo

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Correspondence to Akira Kudo.

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Kudo, A. Introductory review: periostin—gene and protein structure. Cell. Mol. Life Sci. 74, 4259–4268 (2017). https://doi.org/10.1007/s00018-017-2643-5

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