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Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis

Cellular and Molecular Life Sciences volume 74, pages 3769–3787 (2017)Cite this article

Abstract

The gut microbiota is essential to health and has recently become a target for live bacterial cell biotherapies for various chronic diseases including metabolic syndrome, diabetes, obesity and neurodegenerative disease. Probiotic biotherapies are known to create a healthy gut environment by balancing bacterial populations and promoting their favorable metabolic action. The microbiota and its respective metabolites communicate to the host through a series of biochemical and functional links thereby affecting host homeostasis and health. In particular, the gastrointestinal tract communicates with the central nervous system through the gut–brain axis to support neuronal development and maintenance while gut dysbiosis manifests in neurological disease. There are three basic mechanisms that mediate the communication between the gut and the brain: direct neuronal communication, endocrine signaling mediators and the immune system. Together, these systems create a highly integrated molecular communication network that link systemic imbalances with the development of neurodegeneration including insulin regulation, fat metabolism, oxidative markers and immune signaling. Age is a common factor in the development of neurodegenerative disease and probiotics prevent many harmful effects of aging such as decreased neurotransmitter levels, chronic inflammation, oxidative stress and apoptosis—all factors that are proven aggravators of neurodegenerative disease. Indeed patients with Parkinson’s and Alzheimer’s diseases have a high rate of gastrointestinal comorbidities and it has be proposed by some the management of the gut microbiota may prevent or alleviate the symptoms of these chronic diseases.

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Authors and Affiliations

  1. Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, H3A2B4, Canada

    Susan Westfall, Nikita Lomis, Imen Kahouli, Si Yuan Dia & Satya Prakash

  2. Department of Experimental Medicine, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, H3A2B4, Canada

    Nikita Lomis, Imen Kahouli & Satya Prakash

  3. Department of Biochemistry, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Surya Pratap Singh

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  5. Surya Pratap Singh
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  6. Satya Prakash
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Contributions

This review was conceptualized and written by SW with supporting sections written and edited by NL and SYD. Advisement and manuscript suggestions were provided by SPS and SP.

Corresponding author

Correspondence to Satya Prakash.

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The authors declare that there is no conflict of interest or competing financial interests.

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Westfall, S., Lomis, N., Kahouli, I. et al. Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cell. Mol. Life Sci. 74, 3769–3787 (2017). https://doi.org/10.1007/s00018-017-2550-9

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  • DOI: https://doi.org/10.1007/s00018-017-2550-9

Keywords

  • Gut microbiota
  • Probiotics
  • Gut-brain-axis
  • Neurodegeneration
  • Oxidative stress
  • Short-chain fatty acids