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Cellular and Molecular Life Sciences

, Volume 74, Issue 14, pp 2613–2625 | Cite as

Emerging Role of MicroRNAs in mTOR Signaling

  • Yanjie ZhangEmail author
  • Bo Huang
  • Hui-Yun Wang
  • Augustus Chang
  • X. F. Steven ZhengEmail author
Review

Abstract

Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR pathway is common in human cancers, driving uncontrolled proliferation. MicroRNA (miRNA) is a class of short noncoding RNAs that regulate the expression of a wide variety of genes. Deregulation of miRNAs is a hallmark of cancer. Recent studies have revealed interplays between miRNAs and the mTOR pathway during cancer development. Such interactions appear to provide a fine-tuning of various cellular functions and contribute qualitatively to the behavior of cancer. Here we provide an overview of current knowledge regarding the reciprocal relationship between miRNAs and mTOR pathway: regulation of mTOR signaling by miRNAs and control of miRNA biogenesis by mTOR. Further research in this area may prove important for the diagnosis and therapy of human cancer.

Keywords

mTOR MicroRNA Cancer Cell signaling pathway Biomarker 

Abbreviations

AMPK

Adenosine 5′-monophosphate-activated protein kinase

BDNF

Brain-derived neurotrophic factor

DDIT4

DNA damage-inducible transcript 4

4E-BP1

eIF4E-binding protein 1

IGF-1/IGF1R

Insulin-like growth factor 1/insulin-like growth factor 1 receptor

IKKβ

IkB kinaseβ

IRS

Insulin receptor substrate

LKB1

Liver kinase B1

MiRNA

microRNA

mTOR

Mechanistic/mammalian target of rapamycin

mTORC1/2

mTOR complex 1/2

p70S6K

70 kDa ribosomal protein S6 kinase

PDCD4

Programmed cell death 4

PI3K

Phosphoinositide 3-kinase

PRAS40

Proline-rich AKT substrate 40 kDa

PTEN

Phosphatase and tensin homolog

Rheb

Ras homology enriched in brain

Stat3

Signal transducer and activator of transcription 3

TSC1/2

Tuberous sclerosis 1/2

VEGF

Vascular Endothelial Growth Factor

Notes

Acknowledgements

Related work in authors’ laboratories was supported by NIH R01 Grants CA123391, CA166575, and CA173519, the National Natural Science Foundation of China 81672354, 81372600, 81572440, and Shanghai Pujiang Program 15PJ1404900.

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Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Oncology Department, Shanghai Ninth People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina
  2. 2.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouChina
  3. 3.Rutgers Robert Wood Johnson Medical SchoolPiscatawayUSA
  4. 4.Rutgers Cancer Institute of New Jersey, RutgersThe State University of New JerseyNew BrunswickUSA

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