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Interactions between mesenchymal stem cells and the immune system

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Abstract

In addition to being multi-potent, mesenchymal stem cells (MSCs) possess immunomodulatory functions that have been investigated as potential treatments in various immune disorders. MSCs can robustly interact with cells of the innate and adaptive immune systems, either through direct cell–cell contact or through their secretome. In this review, we discuss current findings regarding the interplay between MSCs and different immune cell subsets. We also draw attention to the mechanisms involved.

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Abbreviations

MSCs:

Mesenchymal stem cells;

Sca-1:

Stem cell antigen-1

ESCs:

Embryonic stem cells

iPSCs:

Induced pluripotent stem cells

Th:

T-helper

TGF-β:

Transforming growth factor beta

HGF:

Hepatocyte growth factor

IFN:

Interferon

Treg:

Regulatory T cell

NK:

Natural killer

DC:

Dendritic cell

EAE:

Experimental autoimmune encephalomyelitis

SLE:

Systemic lupus erythematosus

GVHD:

Graft-versus-host disease

TNF:

Tumor necrosis factor

IL:

Interleukin

iNOS:

Nitric oxide synthase

COX:

Cyclooxygenase

NO:

Nitric oxide

PGE2:

Prostaglandin E2

CXCR3:

CXC chemokine receptor3

CCR5:

C-C chemokine receptor type 5

ICAM-1:

Intercellular adhesion molecule 1

VCAM-1:

Vascular cell adhesion molecule 1

IDO:

Indoleamine 2,3-dioxygenase

HLA-G5:

Human leukocyte antigen class I molecule G5

EV:

Extracellular vesicle

TSG6:

Tumor necrosis factor-induced protein 6

Breg:

Regulatory B cell

STAT3:

Signal transducer and activator of transcription 3

Blimp1:

B lymphocyte-induced maturation protein 1

IL-1Ra:

IL-1 receptor antagonist

APC:

Antigen-presenting cell

MIF:

Macrophage migration inhibitory factor.

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Acknowledgements

This study was done with the support of Grants from the China National Basic Research Program (JFYS 2016YFA0100203), the National Natural Science Foundation of China (31272518, 31572399), and the Program of the Shaanxi Province (2015NY157).

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Li, N., Hua, J. Interactions between mesenchymal stem cells and the immune system. Cell. Mol. Life Sci. 74, 2345–2360 (2017). https://doi.org/10.1007/s00018-017-2473-5

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