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Earlier and broader roles of Mesp1 in cardiovascular development

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Abstract

Mesoderm posterior 1 is one of earliest markers of the nascent mesoderm. Its best-known function is driving the onset of the cardiovascular system. In the past decade, new evidence supports that Mesp1 acts earlier with greater breadth in cell fate decisions, and through cell-autonomous and cell non-autonomous mechanisms. This review summarizes these new aspects, with an emphasis on the upstream and downstream regulation around Mesp1 and how they may guide cell fate reprogramming.

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Acknowledgements

I thank Robert J. Schwartz, Shuxing Zhang and M. David Stewart for helpful discussions; Research in my laboratory is supported by a startup fund from University of Houston, multiple American Heart Association grants (11SDG5260033, 16GRNT27760164) and a grant from US Department of Defense (LC140601).

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  1. Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA

    Yu Liu

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Liu, Y. Earlier and broader roles of Mesp1 in cardiovascular development. Cell. Mol. Life Sci. 74, 1969–1983 (2017). https://doi.org/10.1007/s00018-016-2448-y

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