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Nuclear receptors as pharmacological targets, where are we now?

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Abstract

Knowledge of integrative physiology is a major challenge for scientists, as even small deregulation could lead to diseases. Cells communicate with each other to control many processes such as growth, migration, survival, or differentiation. Such interaction could be achieved via several mechanisms either through cell–cell interactions and/or through the signaling of molecules that bind to receptors on the membrane or in the target cells. The produced molecules could have either autocrine, paracrine stimulations, or even act on distant organs (endocrine signaling).

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Authors and Affiliations

  1. INSERM U 1103, Génétique Reproduction et Développement (GReD), Campus Universitaire des Cézeaux, 10 avenue Blaise Pascal, TSA 60026, CS 60026, 63178, Aubière Cedex, France

    David H. Volle

  2. Université Clermont Auvergne, GReD, 63000, Clermont-Ferrand, France

    David H. Volle

  3. Université Clermont Auvergne, GReD, 63170, Aubière, France

    David H. Volle

  4. CNRS, UMR 6293, GReD, 63170, Aubière, France

    David H. Volle

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  1. David H. Volle
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Correspondence to David H. Volle.

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Volle, D.H. Nuclear receptors as pharmacological targets, where are we now?. Cell. Mol. Life Sci. 73, 3777–3780 (2016). https://doi.org/10.1007/s00018-016-2327-6

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  • DOI: https://doi.org/10.1007/s00018-016-2327-6

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