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Axial and limb muscle development: dialogue with the neighbourhood

Abstract

Skeletal muscles are part of the musculoskeletal system which also includes nerves, tendons, connective tissue, bones and blood vessels. Here we review the development of axial and limb muscles in amniotes within the context of their surrounding tissues in vivo. We highlight the reciprocal dialogue mediated by signalling factors between cells of these adjacent tissues and developing muscles and also demonstrate its importance from the onset of muscle cell differentiation well into foetal development. Early embryonic tissues secrete factors which are important regulators of myogenesis. However, later muscle development relies on other tissue collaborators, such as developing nerves and connective tissue, which are in turn influenced by the developing muscles themselves. We conclude that skeletal muscle development in vivo is a compelling example of the importance of reciprocal interactions between developing tissues for the complete and coordinated development of a functional system.

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Acknowledgments

We thank Christine L. Mummery for her critical comments, our team for useful discussion and André B. Gonçalves for the image in Fig. 2a. We also thank John Harris for giving the anti-MyoD antibody. Pax3 antibody was developed by C.P. Ordahl and was obtained from the Developmental Studies Hybridoma Bank, developed under the auspices of the NICHD and maintained by The University of Iowa, Department of Biology, Iowa City, IA52242, USA. M.D. is supported by Fundação para a Ciência e a Tecnologia (FCT) post-doc grant SFRH/BPD/65370/2009 (Portugal). This manuscript is an output of FCT project PTDC/SAU-BID/120130/2010 (Portugal).

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Deries, M., Thorsteinsdóttir, S. Axial and limb muscle development: dialogue with the neighbourhood. Cell. Mol. Life Sci. 73, 4415–4431 (2016). https://doi.org/10.1007/s00018-016-2298-7

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Keywords

  • Embryo
  • Myotome
  • Limb muscle
  • Skeletal myogenesis
  • Neighbouring tissues
  • Paracrine communication