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Melatonin role preventing steatohepatitis and improving liver transplantation results

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Abstract

Liver steatosis is a prevalent process that is induced due to alcoholic or non-alcoholic intake. During the course of these diseases, the generation of reactive oxygen species, followed by molecular damage to lipids, protein and DMA occurs generating organ cell death. Transplantation is the last-resort treatment for the end stage of both acute and chronic hepatic diseases, but its success depends on ability to control ischemia–reperfusion injury, preservation fluids used, and graft quality. Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other because of its efficacy in organs; melatonin has been investigated to improve the outcome of organ transplantation by reducing ischemia–reperfusion injury and due to its synergic effect with organ preservation fluids. Moreover, this indolamine also prevent liver steatosis. That is important because this disease may evolve leading to an organ transplantation. This review summarizes the observations related to melatonin beneficial actions in organ transplantation and ischemic–reperfusion models.

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Acknowledgments

This work was supported by grants from the ‘Gobierno de Aragón’ (Aging and Oxidative Stress Physiology, Grant No. B40) and from the ‘Instituto de Salud Carlos III’ (RD12/0043/0035). Special acknowledgment also is given to the Department of Cellular and Structural Biology of University of Texas Health Science Center at San Antonio for hosting E.E.Z. during the preparation of this review.

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Authors and Affiliations

  1. Department of Pharmacology and Physiology, University of Zaragoza, Calle Domingo Miral s/n, 50009, Saragossa, Spain

    Eduardo Esteban-Zubero & José Joaquín García

  2. Department of Surgery, Gynaecology and Obstetrics, University of Zaragoza, Calle Domingo Miral s/n, 50009, Saragossa, Spain

    Francisco Agustín García-Gil & José Manuel Ramírez

  3. Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, Calle Domingo Miral s/n, 50009, Saragossa, Spain

    Laura López-Pingarrón

  4. Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA

    Moisés Alejandro Alatorre-Jiménez, Dun-Xian Tan & Russel J. Reiter

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  1. Eduardo Esteban-Zubero
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Esteban-Zubero, E., García-Gil, F.A., López-Pingarrón, L. et al. Melatonin role preventing steatohepatitis and improving liver transplantation results. Cell. Mol. Life Sci. 73, 2911–2927 (2016). https://doi.org/10.1007/s00018-016-2185-2

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