Cellular and Molecular Life Sciences

, Volume 73, Issue 4, pp 687–703 | Cite as

Adhesion receptors involved in HSC and early-B cell interactions with bone marrow microenvironment

  • Maria De Grandis
  • Anne-Catherine Lhoumeau
  • Stéphane J. C. Mancini
  • Michel Aurrand-Lions
Review

Abstract

Hematopoiesis takes place in the bone marrow of adult mammals and is the process by which blood cells are replenished every day throughout life. Differentiation of hematopoietic cells occurs in a stepwise manner through intermediates of differentiation that could be phenotypically identified. This has allowed establishing hematopoietic cell classification with hematopoietic stem cells (HSCs) at the top of the hierarchy. HSCs are mostly quiescent and serve as a reservoir for maintenance of lifelong hematopoiesis. Over recent years, it has become increasingly clear that HSC quiescence is not only due to intrinsic properties, but is also mediated by cognate interactions between HSCs and surrounding cells within micro-anatomical sites called “niches”. This hematopoietic/stromal crosstalk model also applies to more mature progenitors such as B cell progenitors, which are thought to reside in distinct “niches”. This prompted many research teams to search for specific molecular mechanisms supporting leuko-stromal crosstalk in the bone marrow and acting at specific stage of differentiation to regulate hematopoietic homeostasis. Here, we review recent data on adhesion mechanisms involved in HSCs and B cell progenitors interactions with surrounding bone marrow stromal cells.

Keywords

Adhesion Niche Hematopoietic stem cell B cell 

Notes

Acknowledgments

The authors apologize to those whose work has not been cited due to space limitation. MDG is supported by a grant from “Fondation de France”. Our laboratory is supported by Inca (# 5940), ARC Foundation (PJA# 20141201990 to MAL; PJA# 20131200298 to SM), SIRIC (# INCa-DGOS-Inserm 6038), PACA Cancéropôle and PACA Region.

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Copyright information

© Springer Basel 2015

Authors and Affiliations

  • Maria De Grandis
    • 1
  • Anne-Catherine Lhoumeau
    • 1
  • Stéphane J. C. Mancini
    • 1
  • Michel Aurrand-Lions
    • 1
  1. 1.Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, Inserm U1068, CNRS UMR7258Aix-Marseille Université UM105MarseilleFrance

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