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Histone methylation modifiers in cellular signaling pathways

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Abstract

Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels of various non-histone proteins, such as effector proteins that play critical roles in cellular signaling networks. Dysregulated histone methylation modifiers alter expression of oncogenes and tumor suppressor genes and change methylation states of effector proteins, frequently resulting in aberrant cellular signaling cascades and cellular transformation. In this review, we summarize the role of histone methylation modifiers in regulating the following signaling pathways: NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα.

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Acknowledgments

We apologize for not reviewing numerous pertinent articles because of space limitations. We are thankful to Kathryn Hale for manuscript editing. The work of this laboratory is supported by grants to M.G.L. from the NIH (R01 GM095659 and R01 CA157919), the Center for Cancer Epigenetics at The University of Texas MD Anderson Cancer Center, and Cancer Prevention and Research Institute of Texas (RP110183) and by a fellowship to H.A. from the Odyssey Program at MD Anderson Cancer Center.

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  1. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA

    Hunain Alam, Bingnan Gu & Min Gyu Lee

  2. Cancer Biology Program, Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX, 77030, USA

    Min Gyu Lee

  3. Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Min Gyu Lee

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  1. Hunain Alam
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Alam, H., Gu, B. & Lee, M.G. Histone methylation modifiers in cellular signaling pathways. Cell. Mol. Life Sci. 72, 4577–4592 (2015). https://doi.org/10.1007/s00018-015-2023-y

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