MUC1 (CD227): a multi-tasked molecule

Abstract

Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.

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Abbreviations

AGR2:

Anterior gradient 2

ALK:

Anaplastic lymphoma kinase

C. jejeni :

Campylobacter jejeni

CA:

Cancer antigen

CASA:

Cancer-associated serum antigen

CD:

Cluster of differentiation

CEA:

Carcinoembryonic antigen

CTL:

Cytotoxic T lymphocyte

DC:

Dendritic cell

EGFR:

Epidermal growth factor receptor

FGF:

Fibroblast growth factor

GalNac:

N-acetyl galactosamine

GlcNAc:

N-acetyl glucosamine

H. pylori :

Helicobacter pylori

HLA:

Human leukocyte antigen

HMFG:

Human milk fat globule

Hsp:

Heat shock protein

IBD:

Inflammatory bowel disease

ICAM-1:

Intercellular adhesion molecule 1

IFN:

Interferon

IL:

Interleukin

Mab:

Monoclonal antibody

MAG:

Myelin-associated glycoprotein

MALT:

Mucosa-associated lymphoid tissue

MAV-1:

Murine adenovirus type 1

MCA:

Mucin-like carcinoma-associated antigen

MDSC:

Myeloid-derived suppressor cell

MGL:

Macrophage galactose lectin

MHC:

Major histocompatibility complex

MSA:

Mammary serum antigen

MUC1:

Human mucin 1

Muc1:

Other species mucin 1

NK:

Natural killer

NMR:

Nuclear magnetic resonance

OSA:

Ovarian serum antigen

P. aeruginosa :

Pseudomonas aeruginosa

RSV:

Respiratory syncytial virus

SEA:

Sea urchin sperm protein-enterokinase-agrin

siRNA:

Small interfering RNA

TF or T:

Thomsen-Friedenreich

TGF:

Transforming growth factor

Th:

T helper

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

Tn:

Monosaccharide of TF

STn:

Sialylated Tn

VEGF:

Vascular endothelial growth factor

VNTR:

Variable number of tandem repeats

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Acknowledgments

The authors would like to thank Prima Biomed Ltd. for their helpful discussions.

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Correspondence to Vasso Apostolopoulos.

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Apostolopoulos, V., Stojanovska, L. & Gargosky, S.E. MUC1 (CD227): a multi-tasked molecule. Cell. Mol. Life Sci. 72, 4475–4500 (2015). https://doi.org/10.1007/s00018-015-2014-z

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Keywords

  • MUC1
  • CD227
  • PEM
  • EMA
  • MUC1 isoforms
  • MUC1 expression
  • MUC1 structure
  • MUC1 and disease
  • MUC1 and pathogens
  • MUC1 and cancer