Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling

Abstract

SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells.

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Acknowledgements

This research was funded by Kungliga Fysiografiska Sällskapet i Lund (JUK), Ollie and Elof Ericssons Stiftelse (JUK), Åke-Wiberg Stiftelse (JUK), Lars Hiertas Minne Stiftelse (JUK), Stiftelsen Olle Engkvist Byggmästare (JUK), Harald Jeanssons Stiftelse and Harald och Greta Jeanssons Stiftelse (JUK), Swedish Childhood Cancer Foundation (JUK), Gunnar Nilsson Cancer Foundation (LR), Swedish Cancer Society (LR), BioCARE cancer network (LR and JUK) and the Swedish Research Council (LR). JUK is a recipient of Assistant Professorship (forskarassistenttjänst) grant from the Swedish Childhood Cancer Foundation.

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Correspondence to Lars Rönnstrand.

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Kazi, J.U., Kabir, N.N. & Rönnstrand, L. Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling. Cell. Mol. Life Sci. 72, 2535–2544 (2015). https://doi.org/10.1007/s00018-015-1882-6

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Keywords

  • SLAP-2
  • FLT3
  • c-KIT
  • PDGFR
  • EPHA2
  • EPOR
  • CSF1R
  • SYK