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Cellular and Molecular Life Sciences

, Volume 72, Issue 2, pp 327–337 | Cite as

Histone chaperone CAF-1: essential roles in multi-cellular organism development

  • Zhongsheng Yu
  • Jiyong Liu
  • Wu-Min Deng
  • Renjie Jiao
Review

Abstract

More and more studies have shown chromatin remodelers and histone modifiers play essential roles in regulating developmental patterns by organizing specific chromosomal architecture to establish programmed transcriptional profiles, with implications that histone chaperones execute a coordinating role in these processes. Chromatin assembly factor-1 (CAF-1), an evolutionarily conserved three-subunit protein complex, was identified as a histone chaperone coupled with DNA replication and repair in cultured mammalian cells and yeasts. Interestingly, recent findings indicate CAF-1 may have important regulatory roles during development by interacting with specific transcription factors and epigenetic regulators. In this review, we focus on the essential roles of CAF-1 in regulating heterochromatin organization, asymmetric cell division, and specific signal transduction through epigenetic modulations of the chromatin. In the end, we aim at providing a current image of facets of CAF-1 as a histone chaperone to orchestrate cell proliferation and differentiation during multi-cellular organism development.

Keywords

Heterochromatin Signal transduction Cell proliferation Cell differentiation Epigenetic regulation Genome stability 

Notes

Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (NSFC) [Nos. 31271573, 31228015, 31201007, 81470846] and the 973 Program [2012CB825504]. We are grateful to Gabriel Calvin and Jen Kennedy for critical reading of the manuscript. We thank the anonymous reviewers for constructive suggestions.

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Copyright information

© Springer Basel 2014

Authors and Affiliations

  • Zhongsheng Yu
    • 1
    • 2
  • Jiyong Liu
    • 1
    • 3
  • Wu-Min Deng
    • 4
  • Renjie Jiao
    • 1
    • 2
    • 3
  1. 1.State Key Laboratory of Brain and Cognitive Science, Institute of BiophysicsThe Chinese Academy of SciencesBeijingChina
  2. 2.University of Chinese Academy of SciencesBeijingChina
  3. 3.Guangzhou Hoffmann Institute of Immunology, School of Basic SciencesGuangzhou Medical UniversityGuangzhouChina
  4. 4.Department of Biological ScienceFlorida State UniversityTallahasseeUSA

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