DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist

Abstract

DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.

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Acknowledgments

We would like to thank Nikolaos Benetatos MD for his helpful comments. We apologize to those authors whose work has not been cited.

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Benetatos, L., Vartholomatos, G. & Hatzimichael, E. DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist. Cell. Mol. Life Sci. 71, 4421–4430 (2014). https://doi.org/10.1007/s00018-014-1698-9

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Keywords

  • DLK1-DIO3
  • MEG3
  • Pluripotency
  • Genomic imprinting
  • MicroRNAs
  • Stem cells
  • Reprogramming
  • Induced pluripotent stem cells