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Small Rho GTPases in the control of cell shape and mobility

Cellular and Molecular Life Sciences volume 71, pages 1703–1721 (2014)Cite this article

Abstract

Rho GTPases are a class of evolutionarily conserved proteins comprising 20 members, which are predominantly known for their role in regulating the actin cytoskeleton. They are primarily regulated by binding of GTP/GDP, which is again controlled by regulators like GEFs, GAPs, and RhoGDIs. Rho GTPases are thus far well known for their role in the regulation of actin cytoskeleton and migration. Here we present an overview on the role of Rho GTPases in regulating cell shape and plasticity of cell migration. Finally, we discuss the emerging roles of ubiquitination and sumoylation in regulating Rho GTPases and cell migration.

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Acknowledgments

The work in KR’s lab was funded through ENP programme grant RA1739/1-1 from the DFG and a PLUS3 grant from Boehringer Ingelheim Stiftung to KR. We apologize to colleagues whose work could not be cited due to space constraints.

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  1. Cell Death Signaling Group, Institute of Biochemistry II, Goethe University Medical School, Frankfurt, Germany

    Arun Murali & Krishnaraj Rajalingam

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  1. Arun Murali
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Correspondence to Krishnaraj Rajalingam.

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Murali, A., Rajalingam, K. Small Rho GTPases in the control of cell shape and mobility. Cell. Mol. Life Sci. 71, 1703–1721 (2014). https://doi.org/10.1007/s00018-013-1519-6

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  • DOI: https://doi.org/10.1007/s00018-013-1519-6

Keywords

  • Rac1
  • RhoA
  • Cdc42
  • Rho GTPases
  • Cell shape
  • Cell migration
  • Plasticity
  • Amoeboid
  • Mesenchymal
  • Metastases