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Cellular and Molecular Life Sciences

, Volume 70, Issue 20, pp 3871–3882 | Cite as

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

  • Fábio G. Teixeira
  • Miguel M. Carvalho
  • Nuno Sousa
  • António J. Salgado
Review

Abstract

The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already demonstrated, both in vitro and in vivo, that MSCs are able to secrete a broad range of neuroregulatory factors that promote an increase in neurogenesis, inhibition of apoptosis and glial scar formation, immunomodulation, angiogenesis, neuronal and glial cell survival, as well as relevant neuroprotective actions on different pathophysiological contexts. Considering their protective action in lesioned sites, MSCs’ secretome might also improve the integration of local progenitor cells in neuroregeneration processes, opening a door for their future use as therapeutical strategies in human clinical trials. Thus, in this review we analyze the current understanding of MSCs secretome as a new paradigm for the treatment of CNS neurodegenerative diseases.

Keywords

Mesenchymal stem cells Secretome Neurodegenerative diseases Neuroregeneration 

Notes

Acknowledgments

We thank to the Portuguese Foundation for Science and Technology (FCT) for: Ciência 2007 program (A.J. Salgado), Grant PTDC/SAU-BMA/114059/2009 and, pre-doctoral fellowships to F.G. Teixeira (SFRH/BD/69637/2010) and Miguel Carvalho (SFRH/BD/51061/2010).

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Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Fábio G. Teixeira
    • 1
    • 2
  • Miguel M. Carvalho
    • 1
    • 2
  • Nuno Sousa
    • 1
    • 2
  • António J. Salgado
    • 1
    • 2
  1. 1.Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of MinhoBragaPortugal
  2. 2.ICVS/3B’sPT Government Associate LaboratoryBraga/GuimarãesPortugal

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