Abstract
Established views on the maintenance of immunological memory have been challenged recently by the description of memory plasma cells and memory T helper (Th) lymphocytes residing in the bone marrow (BM) in dedicated survival niches, resting in terms of proliferation and migration. While memory plasma cells are no longer reactive to antigen, memory Th lymphocytes are in a state of attentive rest, and can be reactivated fast and efficiently. Here, we discuss the signals controlling these resting states, which the memory lymphocytes receive from their microenvironment.
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Abbreviations
- BM:
-
Bone marrow
- Th:
-
T helper
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Acknowledgments
This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology (Grants-in-Aid: for Scientific Research on Priority Areas #22021011 and Young Scientists (A) #22689014), Uehara Memorial Foundation, Takeda Science Foundation, and Astellas Foundation for Research on Metabolic Disorders (Japan) and by Deutsche Forschungsgemeinschaft for support through SFB 650 and the BMBF for support through FORSYS (Germany). K.T. was a Research Fellow of the Alexander von Humboldt Foundation.
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Tokoyoda, K., Radbruch, A. Signals controlling rest and reactivation of T helper memory lymphocytes in bone marrow. Cell. Mol. Life Sci. 69, 1609–1613 (2012). https://doi.org/10.1007/s00018-012-0969-6
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DOI: https://doi.org/10.1007/s00018-012-0969-6