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Emerging functions of matricellular proteins

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References

  1. Larsen M, Artym VV, Green JA, Yamada KM (2006) The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr Opin Cell Biol 18:463–471

    Article  PubMed  CAS  Google Scholar 

  2. Schwartz MA (2010) Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol 2:a005066

    Article  PubMed  CAS  Google Scholar 

  3. Kim SH, Turnbull J, Guimond S (2011) Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. J Endocrinol 209:139–151

    Article  PubMed  CAS  Google Scholar 

  4. Mecham RP (ed) (2011) The extracellular matrix: an overview. Springer, Berlin

    Google Scholar 

  5. Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS (2009) Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell 5:17–26

    Article  PubMed  CAS  Google Scholar 

  6. Kenny PA, Bissell MJ (2003) Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer 107:688–695

    Article  PubMed  CAS  Google Scholar 

  7. Bornstein P (1995) Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J Cell Biol 130:503–506

    Article  PubMed  CAS  Google Scholar 

  8. Roberts DD, Lau LF (2011) Matricellular proteins. In: Mecham RP (ed) The extracellular matrix: an overview. Springer, Berlin, pp 369–413

    Chapter  Google Scholar 

  9. Carlson CB, Lawler J, Mosher DF (2008) Structures of thrombospondins. Cell Mol Life Sci 65:672–686

    Article  PubMed  CAS  Google Scholar 

  10. Posey KL, Yang Y, Veerisetty AC, Sharan SK, Hecht JT (2008) Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations. Cell Mol Life Sci 65:687–699

    Article  PubMed  CAS  Google Scholar 

  11. Kazerounian S, Yee KO, Lawler J (2008) Thrombospondins in cancer. Cell Mol Life Sci 65:700–712

    Article  PubMed  CAS  Google Scholar 

  12. Bonnefoy A, Moura R, Hoylaerts MF (2008) The evolving role of thrombospondin-1 in hemostasis and vascular biology. Cell Mol Life Sci 65:713–727

    Article  PubMed  CAS  Google Scholar 

  13. Isenberg JS, Frazier WA, Roberts DD (2008) Thrombospondin-1: a physiological regulator of nitric oxide signaling. Cell Mol Life Sci 65:728–742

    Article  PubMed  CAS  Google Scholar 

  14. Calzada MJ, Zhou L, Sipes JM, Zhang J, Krutzsch HC, Iruela-Arispe ML, Annis DS, Mosher DF, Roberts DD (2004) α4β1 integrin mediates selective endothelial cell responses to thrombospondins in vitro and modulates angiogenesis in vivo. Circ Res 94:462–470

    Article  PubMed  CAS  Google Scholar 

  15. Lawler J, Sunday M, Thibert V, Duquette M, George EL, Rayburn H, Hynes RO (1998) Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest 101:982–992

    Article  PubMed  CAS  Google Scholar 

  16. Kyriakides TR, Zhu YH, Smith LT, Bain SD, Yang Z, Lin MT, Danielson KG, Iozzo RV, LaMarca M, McKinney CE, Ginns EI, Bornstein P (1998) Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J Cell Biol 140:419–430

    Article  PubMed  CAS  Google Scholar 

  17. Frolova EG, Pluskota E, Krukovets I, Burke T, Drumm C, Smith JD, Blech L, Febbraio M, Bornstein P, Plow EF, Stenina OI (2010) Thrombospondin-4 regulates vascular inflammation and atherogenesis. Circ Res 107:1313–1325

    Article  PubMed  CAS  Google Scholar 

  18. Posey KL, Hankenson K, Veerisetty AC, Bornstein P, Lawler J, Hecht JT (2008) Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen. Am J Pathol 172:1664–1674

    Article  PubMed  CAS  Google Scholar 

  19. Isenberg JS, Martin-Manso G, Maxhimer JB, Roberts DD (2009) Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies. Nat Rev Cancer 9:182–194

    Article  PubMed  CAS  Google Scholar 

  20. Stenina OI, Topol EJ, Plow EF (2007) Thrombospondins, their polymorphisms, and cardiovascular disease. Arterioscler Thromb Vasc Biol 27:1886–1894

    Article  PubMed  CAS  Google Scholar 

  21. Jones PL, Jones FS (2000) Tenascin-C in development and disease: gene regulation and cell function. Matrix Biol 19:581–596

    Article  PubMed  CAS  Google Scholar 

  22. Bradshaw AD (2009) The role of SPARC in extracellular matrix assembly. J Cell Commun Signal 3:239–246

    Article  PubMed  Google Scholar 

  23. Arnold SA, Brekken RA (2009) SPARC: a matricellular regulator of tumorigenesis. J Cell Commun Signal 3:255–273

    Article  PubMed  Google Scholar 

  24. Holbourn KP, Acharya KR, Perbal B (2008) The CCN family of proteins: structure-function relationships. Trends Biochem Sci 33:461–473

    Article  PubMed  CAS  Google Scholar 

  25. Apte SS (2009) A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily-functions and mechanisms. J Biol Chem 284:31493–31497

    Article  PubMed  CAS  Google Scholar 

  26. Rios H, Koushik SV, Wang H, Wang J, Zhou HM, Lindsley A, Rogers R, Chen Z, Maeda M, Kruzynska-Frejtag A, Feng JQ, Conway SJ (2005) periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol 25:11131–11144

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

Cited work in the author’s laboratory was supported by the Intramural Research Program of the Center for Cancer Research, National Cancer Institute, NIH. Conference support was provided by DK089753-01, the Center for Cancer Research, and the NIH Office of Rare Diseases Research.

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  1. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10 Room 2A33, 10 Center Dr MSC1500, Bethesda, MD, 20892, USA

    David D. Roberts

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Correspondence to David D. Roberts.

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Roberts, D.D. Emerging functions of matricellular proteins. Cell. Mol. Life Sci. 68, 3133–3136 (2011). https://doi.org/10.1007/s00018-011-0779-2

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