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Biochemistry of the non-mevalonate isoprenoid pathway

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Abstract

The non-mevalonate pathway of isoprenoid (terpenoid) biosynthesis is essential in many eubacteria including the major human pathogen, Mycobacterium tuberculosis, in apicomplexan protozoa including the Plasmodium spp. causing malaria, and in the plastids of plants. The metabolic route is absent in humans and is therefore qualified as a promising target for new anti-infective drugs and herbicides. Biochemical and structural knowledge about all enzymes involved in the pathway established the basis for discovery and development of inhibitors by high-throughput screening of compound libraries and/or structure-based rational design.

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Acknowledgments

Financial support by the Deutsche Forschungsgemeinschaft, and the Hans-Fischer-Gesellschaft is gratefully acknowledged.

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  1. Felix Rohdich

    Present address: Merck KgaA, Darmstadt, Germany

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  1. Department Chemie, Lehrstuhl für Biochemie, Center for Integrated Protein Science München, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany

    Tobias Gräwert, Michael Groll, Adelbert Bacher & Wolfgang Eisenreich

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Gräwert, T., Groll, M., Rohdich, F. et al. Biochemistry of the non-mevalonate isoprenoid pathway. Cell. Mol. Life Sci. 68, 3797–3814 (2011). https://doi.org/10.1007/s00018-011-0753-z

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