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Dynamics of the interaction of γδ T cells with their neighbors in vivo

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Abstract

γδ T cells are a diverse component of the immune system in humans and mice with presumably important but still largely unknown functions. Understanding the dynamic interaction of γδ T cells with their neighbors should help to understand their physiological role. This review addresses recent advances and strategies to visualize the dynamic interactions of γδ T cells with their neighbors in vivo. Current knowledge regarding the dynamic contacts of tissue resident γδ T cells and epithelial cells, but also of the communication between circulating γδ T cells and DCs, monocytes and FoxP3+ regulatory T cells is revisited with emphasis on the role of γδ T cell motility.

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Acknowledgments

Many thanks to Tim Worbs, Andreas Krueger and Vijaykumar Chennupati for helpful discussions and for carefully reading the MS. The group of I.P. is supported by the Deutsche Forschungsgemeinschaft, Grant SFB621-A14.

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    Immo Prinz

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Prinz, I. Dynamics of the interaction of γδ T cells with their neighbors in vivo. Cell. Mol. Life Sci. 68, 2391–2398 (2011). https://doi.org/10.1007/s00018-011-0701-y

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