Skip to main content
Log in

γδ T-cells: cross-talk between innate and adaptive immunity

  • Multi-author review
  • Published:
Cellular and Molecular Life Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Smith-Garvin JE, Koretzky GA, Jordan MS (2009) T cell activation. Annu Rev Immunol 27:591–619

    Article  PubMed  CAS  Google Scholar 

  2. Mazza C, Malissen B (2007) What guides MHC-restricted TCR recognition? Semin Immunol 19:225–236

    Article  PubMed  CAS  Google Scholar 

  3. O’Shea JJ, Paul WE (2010) Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327:1098–1102

    Article  PubMed  Google Scholar 

  4. Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L (1986) A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature 322:179–181

    Article  PubMed  CAS  Google Scholar 

  5. Hayday AC (2000) γδ T cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol 18:975–1026

    Article  PubMed  CAS  Google Scholar 

  6. Kabelitz D, Bender A, Schondelmaier S, Schoel B, Kaufmann SHE (1990) A large fraction of human peripheral blood TCR γ/δ-positive T cells is activated by Mycobacterium tuberculosis but not by its 65 kDa heat shock protein. J Exp Med 171:667–679

    Article  PubMed  CAS  Google Scholar 

  7. Constant P, Davodeau F, Peyrat MA, Poquet Y, Puzo G, Bonneville M, Fournié JJ (1994) Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science 264:267–270

    Article  PubMed  CAS  Google Scholar 

  8. Gober HJ, Kistowska M, Angman L, Jenö P, Mori L, De Libero G (2003) Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells. J Exp Med 197:163–168

    Article  PubMed  CAS  Google Scholar 

  9. Wrobel P, Shojaei H, Schittek B, Gieseler F et al (2007) Lysis of a broad range of epithelial tumour cells by human γδ T cells: involvement of NKG2D ligands and T cell receptor- versus NKG2D-dependent recognition. Scand J Immunol 66:320–328

    Article  PubMed  CAS  Google Scholar 

  10. Kabelitz D, Wesch D, He W (2007) Perspectives of γδ T cells in tumor immunology. Cancer Res 67:5–8

    Article  PubMed  CAS  Google Scholar 

  11. Dieli F, Vermijlen D, Fulfaro F, Caccamo N, Meraviglia S, Cicero G, Roberts A, Buccheri S, D’Asaro M, Gebbia N, Salerno A, Eberl M, Hayday AC (2007) Targeting human γδ T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Res 67:7450–7457

    Article  PubMed  CAS  Google Scholar 

  12. Brandes M, Willimann K, Bioley G, Levy N, Eberl M, Luo M, Tampe R, Levy F, Romero P, Moser B (2009) Cross-presenting human γδ T cells induce robust CD8+ αβ T cell responses. Proc Natl Acad Sci USA 106:2307–2312

    Article  PubMed  CAS  Google Scholar 

  13. Casetti R, Agrati C, Wallace M, Sacchi A, Martini F, Rinaldi A, Malkovsky M (2009) Cutting edge: TGF-β1 and IL-15 induce FOXP3+ γδ regulatory T cells in the presence of antigen stimulation. J Immunol 183:3574–3577

    Article  PubMed  CAS  Google Scholar 

  14. Wesch D, Beetz S, Oberg HH, Marget M, Krengel K, Kabelitz D (2006) Direct costimulatory effect of TLR3 ligand poly(I:C) on human γδ T lymphocytes. J Immunol 176:1348–1354

    PubMed  CAS  Google Scholar 

  15. Deetz CO, Hebbeler AM, Propp NA, Cairo C, Tikhonov I, Pauza CD (2006) Gamma interferon secretion by human Vγ2Vδ2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-like receptor 2 agonist Pam3Cys. Infect Immun 74:4505–4511

    Article  PubMed  CAS  Google Scholar 

  16. Kerns HMM, Jutila MA, Hedges JF (2009) The distinct response of γδ T cells to the NOD2 agonist muramyl dipeptide. Cell Immunol 257:38–43

    Article  PubMed  CAS  Google Scholar 

  17. Marischen L, Wesch D, Oberg HH, Rosenstiel P, Trad A, Shomali M, Grötzinger J, Janssen O, Tchikov V, Schütze S, Kabelitz D (2011) Functional expression of NOD2 in freshly isolated human peripheral blood γδ T-cells. Scand J Immunol. doi:10.1111/j.1365-3083.2011.02560.x.

Download references

Acknowledgments

Cited work from the author’s laboratory was supported by the Deutsche Forschungsgemeinschaft through grant KA 502/8-3 and the Cluster of Excellence “Inflammation-at-Interfaces”

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dieter Kabelitz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kabelitz, D. γδ T-cells: cross-talk between innate and adaptive immunity. Cell. Mol. Life Sci. 68, 2331–2333 (2011). https://doi.org/10.1007/s00018-011-0696-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-011-0696-4

Keywords

Navigation