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The role of HLA-G in immunity and hematopoiesis

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Abstract

The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto–maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis.

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Abbreviations

HLA-G:

Human leukocyte antigen G

NK cell:

Natural killer cell

IS:

Immunological synapse

ILT:

Immunoglobulin-like transcript

B2M:

β2-Microglobulin

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Acknowledgment

This work was supported by the Commissariat a l’energie atomique et aux energies alternatives (CEA).

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Authors and Affiliations

  1. CEA, I2BM, Service de Recherches en Hemato-Immunologie, 75475, Paris, France

    Edgardo D. Carosella, Nathalie Rouas-Freiss, Joel LeMaoult, Catherine Menier & Benoit Favier

  2. UMR_E, Universite Paris 7, IUH, Hopital Saint-Louis, Paris, France

    Edgardo D. Carosella, Nathalie Rouas-Freiss, Joel LeMaoult, Catherine Menier & Benoit Favier

  3. Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy

    Silvia Gregori

  4. CEA-SRHI, Hopital St. Louis, 1 Av Claude Vellefaux, 75010, Paris, France

    Edgardo D. Carosella

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  1. Edgardo D. Carosella
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  2. Silvia Gregori
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  3. Nathalie Rouas-Freiss
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  5. Catherine Menier
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Correspondence to Edgardo D. Carosella.

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C. Menier and B. Favier have contributed equally to this work.

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Carosella, E.D., Gregori, S., Rouas-Freiss, N. et al. The role of HLA-G in immunity and hematopoiesis. Cell. Mol. Life Sci. 68, 353–368 (2011). https://doi.org/10.1007/s00018-010-0579-0

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