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The ING family tumor suppressors: from structure to function

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Abstract

The INhibitor of Growth (ING) proteins belong to a well-conserved family which presents in diverse organisms with several structural and functional domains for each protein. The ING family members are found in association with many cellular processes. Thus, the ING family proteins are involved in regulation of gene transcription, DNA repair, tumorigenesis, apoptosis, cellular senescence and cell cycle arrest. The ING proteins have multiple domains that are potentially capable of binding to many partners. It is conceivable, therefore, that such proteins could function similarly within protein complexes. In this case, within this family, each function could be attributed to a specific domain. However, the role of ING domains is not definitively clear. In this review, we summarize recent advances in structure–function relationships in ING proteins. For each domain, we describe the known biological functions and the approaches utilized to identify the functions associated with ING proteins.

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Acknowledgments

This work was supported by the Canadian Institutes of Health Research (MOP-84559 and MOP-93810) and the Canadian Dermatology Foundation to G. Li. R.P.C.W. is a recipient of a Terry Fox Foundation Research Studentship from Canadian Cancer Society Research Institute.

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  1. Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 2660 Oak Street, Vancouver, BC, V6H 3Z6, Canada

    Almass-Houd Aguissa-Touré, Ronald P. C. Wong & Gang Li

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  1. Almass-Houd Aguissa-Touré
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  2. Ronald P. C. Wong
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Correspondence to Gang Li.

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Aguissa-Touré, AH., Wong, R.P.C. & Li, G. The ING family tumor suppressors: from structure to function. Cell. Mol. Life Sci. 68, 45–54 (2011). https://doi.org/10.1007/s00018-010-0509-1

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