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Cellular and Molecular Life Sciences

, Volume 67, Issue 24, pp 4197–4211 | Cite as

Cartilage biology, pathology, and repair

  • Daniel Umlauf
  • Svetlana Frank
  • Thomas Pap
  • Jessica Bertrand
Review

Abstract

Osteoarthritis is one of the most common forms of musculoskeletal disease and the most prominent type of arthritis encountered in all countries. Although great efforts have been made to investigate cartilage biology and osteoarthritis pathology, the treatment has lagged behind that of other arthritides, as there is a lack of effective disease-modifying therapies. Numerous approaches for dealing with cartilage degradation have been tried, but enjoyed very little success to develop approved OA treatments with not only symptomatic improvement but also structure-modifying effect. In this review we discuss the most recent findings regarding the regulation of cartilage biology and pathology and highlight their potential therapeutic values.

Keywords

Osteoarthritis Cartilage Cartilage repair Disease modifying drugs 

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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Daniel Umlauf
    • 1
  • Svetlana Frank
    • 1
  • Thomas Pap
    • 1
  • Jessica Bertrand
    • 1
  1. 1.Institute of Experimental Musculoskeletal Medicine IEMM, University Hospital MuensterMuensterGermany

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