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Transgenic mouse models of multiple sclerosis

Cellular and Molecular Life Sciences volume 67, pages 4011–4034 (2010)Cite this article

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease affecting the central nervous system (CNS) and a frequent cause of neurological disability in young adults. Multifocal inflammatory lesions in the CNS white matter, demyelination, oligodendrocyte loss, axonal damage, as well as astrogliosis represent the histological hallmarks of the disease. These pathological features of MS can be mimicked, at least in part, using animal models. This review discusses the current concepts of the immune effector mechanisms driving CNS demyelination in murine models. It highlights the fundamental contribution of transgenesis in identifying the mediators and mechanisms involved in the pathophysiology of MS models.

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Abbreviations

AICD:

Activation-induced cell death

APC:

Antigen presenting cell

BBB:

Blood–brain barrier

CMV:

Cytomegalovirus

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

DC:

Dendritic cell

EAE:

Experimental autoimmune encephalomyelitis

EBV:

Epstein–Barr virus

GFAP:

Glial fibrillary acidic protein

GFP:

Green fluorescent protein

GTP:

Guanosine tri-phosphate

HA:

Hemagglutinin

HI:

Haemophilus influenzae

LCMV:

Lymphocytic choriomeningitis virus

MBP:

Myelin basic protein

MOG:

Myelin oligodendrocyte glycoprotein

mAb:

Monoclonal antibody

MS:

Multiple sclerosis

NF-L:

Neurofilament light

NF-M:

Neurofilament medium

NSE:

Neuron-specific enolase

ODC:

Oligodendrocyte

OVA:

Ovalbumin

PLP:

Myelin proteolipid protein

ROR:

Retinoic acid receptor-related orphan nuclear receptor

TMEV:

Theiler’s murine encephalomyelitis virus

TNFRI:

TNF receptor I

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Acknowledgments

Research by R.S.L. and L.T.M. is supported by the European Union: FP6 Neuropromise, SUDOE Immunonet, the National Health and Medical Research Institute (INSERM), the FRM, and ARSEP. BP is a recipient of an ARSEP fellowship. T.S. is supported by the European Union.

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  1. Institut National de la Santé et de la Recherche Médicale, Unité 563, Toulouse, France

    Tanja Scheikl, Béatrice Pignolet, Lennart T. Mars & Roland S. Liblau

  2. Université Toulouse III, Paul Sabatier, Toulouse, France

    Tanja Scheikl, Béatrice Pignolet, Lennart T. Mars & Roland S. Liblau

  3. INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse Purpan, Bât. B, CHU Purpan, BP 3028, 31024, Toulouse Cedex 3, France

    Roland S. Liblau

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  1. Tanja Scheikl
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Scheikl, T., Pignolet, B., Mars, L.T. et al. Transgenic mouse models of multiple sclerosis. Cell. Mol. Life Sci. 67, 4011–4034 (2010). https://doi.org/10.1007/s00018-010-0481-9

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  • DOI: https://doi.org/10.1007/s00018-010-0481-9

Keywords

  • Transgenesis
  • Multiple sclerosis
  • EAE
  • CNS
  • T cells
  • Autoimmunity