Abstract.
Chronic granulomatous disease is an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal infections and disordered inflammation. We propose that NADPH oxidase has a key role in regulating acute neutrophilic and T cell responses, which in turn restrains fungal growth and calibrates the inflammatory response to minimize injury and allergy. In this model, superoxide-induced activation of indoleamine 2,3-dioxygenase (IDO) is a central mechanism by which the optimal balance of antifungal host defense and immune tolerance occurs. This model is based on studies in mice and requires correlation in humans.
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Received 18 August 2008; received after revision 29 November 2008; accepted 16 December 2008
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Segal, B.H., Romani, L. & Puccetti, P. Chronic granulomatous disease. Cell. Mol. Life Sci. 66, 553 (2009). https://doi.org/10.1007/s00018-009-8506-y
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DOI: https://doi.org/10.1007/s00018-009-8506-y