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Mammalian iron transport

  • Gregory Jon AndersonEmail author
  • Christopher D. Vulpe
Review

Abstract

Iron is essential for basic cellular processes but is toxic when present in excess. Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins. Non-transferrin-bound iron can also be taken up efficiently by cells, although the mechanism is poorly understood. Cells can divest themselves of iron via the iron export protein ferroportin in conjunction with an iron oxidase. The linking of an oxidoreductase to a membrane permease is a common theme in membrane iron transport. At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma.

Keywords

Iron transport Transferrin DMT1 Ferroportin Hepcidin Heme transport Iron oxidoreductase 

Notes

Acknowledgment

G.J.A. is the recipient of a Senior Research Fellowship from the National Health and Medical Research Council of Australia.

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Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  1. 1.Iron Metabolism Laboratory, Queensland Institute of Medical ResearchPO Royal Brisbane HospitalBrisbaneAustralia
  2. 2.Department of Nutritional Science and ToxicologyUniversity of CaliforniaBerkeleyUSA

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