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FHA-RING ubiquitin ligases in cell division cycle control

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Abstract.

Despite the common occurrence of forkhead associated (FHA) phosphopeptide-binding domains and really interesting new gene (RING) E3 ubiquitin ligase domains, gene products containing both an N-terminal FHA domain and C-terminal RING domain constitute a highly distinctive intersection. Characterized FHA-RING ligases include the two vertebrate proteins, Checkpoint with FHA and RING (Chfr) and RING finger 8 (Rnf8), as well as three fungal proteins, Defective in mitosis (Dma1), Chf1 and Chf2. These FHA-RING ligases play roles in negative regulation of the cell division cycle, apparently by coupling protein phosphorylation events to specific ubiquitylation of target proteins. Here, the available data on upstream and downstream regulation of and by FHA-RING ligases are reviewed.

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Authors and Affiliations

  1. Departments of Genetics and Biochemistry and Norris Cotton Cancer Center, Dartmouth Medical School, Rubin 733–HB7937, Lebanon, NH, 03756, USA

    L. Brooks III, E. G. Heimsath Jr. & C. Brenner

  2. Altus Pharmaceuticals, Cambridge, MA, 02139, USA

    G. L. Loring

Authors
  1. L. Brooks III
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  2. E. G. Heimsath Jr.
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  3. G. L. Loring
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  4. C. Brenner
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Corresponding author

Correspondence to C. Brenner.

Additional information

Received 24 April 2008; received after revision 18 June 2008; accepted 20 June 2008

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Brooks, L., Heimsath, E.G., Loring, G.L. et al. FHA-RING ubiquitin ligases in cell division cycle control. Cell. Mol. Life Sci. 65, 3458–3466 (2008). https://doi.org/10.1007/s00018-008-8220-1

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  • DOI: https://doi.org/10.1007/s00018-008-8220-1

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