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Cellular and Molecular Life Sciences

, Volume 65, Issue 15, pp 2407–2418 | Cite as

Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression

  • N. Yu
  • M.-L. Zhu
  • B. Johnson
  • Y.-P. Liu
  • R. O. Jones
  • H.-B. Zhao
Research Article

Abstract.

Salicylate (aspirin) can reversibly eliminate outer hair cell (OHC) electromotility to induce hearing loss. Prestin is the OHC electromotility motor protein. Here we report that, consistence with increase in distortion product otoacoustic emission, long-term administration of salicylate can increase prestin expression and OHC electromotility. The prestin expression at the mRNA and protein levels was increased by three- to four-fold. In contrast to the acute inhibition, the OHC electromotility associated charge density was also increased by 18%. This incremental increase was reversible. After cessation of salicylate administration, the prestin expression returned to normal. We also found that long-term administration of salicylate did not alter cyclooxygenase (Cox) II expression but down-regulated NF-κB and increased nuclear transcription factors c-fos and egr-1. The data suggest that prestin expression in vivo is dynamically up-regulated to increase OHC electromotility in long-term administration of salicylate via the Cox-II-independent pathways.

Keywords.

Prestin outer hair cell electromotility salicylate aspirin functional dependence hearing tinnitus 

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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • N. Yu
    • 1
    • 2
  • M.-L. Zhu
    • 1
  • B. Johnson
    • 1
  • Y.-P. Liu
    • 1
  • R. O. Jones
    • 1
  • H.-B. Zhao
    • 1
  1. 1.Department of Surgery, OtolaryngologyUniversity of Kentucky Medical CenterLexingtonUSA
  2. 2.Department of Otorhinolaryngology, Institute of OtolaryngologyChinese PLA General HospitalBeijingP. R. of China

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