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The magic of the hypoxia-signaling cascade

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All organisms respond to changes in their environment by activating complex signaling cascades. The “hypoxia-signaling cascade” is activated in response to low oxygen availability and this activation is central to maintaining oxygen homeostasis and hence to survival. By regulating the transcriptional complex hypoxia-inducible factor, hypoxia is associated with several physiopathological processes. Several strategies, based on the targeting of the hypoxia-signaling cascade, have been developed to treat these pathologies. Our review summarize different aspects of the hypoxic pathway.

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Correspondence to E. Berra.

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Received 11 October 2007; received after revision 21 November 2007; accepted 23 November 2007

E. Benizri, A. Ginouvès: These authors contributed equally to this work.

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Benizri, E., Ginouvès, A. & Berra, E. The magic of the hypoxia-signaling cascade. Cell. Mol. Life Sci. 65, 1133–1149 (2008).

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