Skip to main content

Advertisement

Log in

The magic of the hypoxia-signaling cascade

  • Review
  • Published:
Cellular and Molecular Life Sciences Aims and scope Submit manuscript

Abstract.

All organisms respond to changes in their environment by activating complex signaling cascades. The “hypoxia-signaling cascade” is activated in response to low oxygen availability and this activation is central to maintaining oxygen homeostasis and hence to survival. By regulating the transcriptional complex hypoxia-inducible factor, hypoxia is associated with several physiopathological processes. Several strategies, based on the targeting of the hypoxia-signaling cascade, have been developed to treat these pathologies. Our review summarize different aspects of the hypoxic pathway.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. Berra.

Additional information

Received 11 October 2007; received after revision 21 November 2007; accepted 23 November 2007

E. Benizri, A. Ginouvès: These authors contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Benizri, E., Ginouvès, A. & Berra, E. The magic of the hypoxia-signaling cascade. Cell. Mol. Life Sci. 65, 1133–1149 (2008). https://doi.org/10.1007/s00018-008-7472-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-008-7472-0

Keywords.

Navigation