Skip to main content
Log in

Antizyme inhibitor: mysterious modulator of cell proliferation

  • Review
  • Published:
Cellular and Molecular Life Sciences CMLS Aims and scope Submit manuscript


In contrast to the considerable interest in the oncogene ornithine decarboxylase (ODC) and in the family of antizymes with regard to cell proliferation and tumorigenesis, the endogenous antizyme inhibitor (AZI) has been less well studied. AZI is highly homologous to the enzyme ODC but does not possess any decarboxylase activity. Elevated ODC activity is associated with most forms of human malignancies. Antizymes bind ODC, inhibit ODC activity and promote the ubiquitin-independent degradation of ODC. Consequently they are proposed as tumor suppressors. In particular, the most studied member of the antizyme family, antizyme 1, has been demonstrated to play a role in tumor suppression. AZI inactivates all members of the antizyme family, reactivates ODC and prevents the proteolytic degradation of ODC, which may suggest a role for AZI in tumor progression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations


Corresponding author

Correspondence to U. Mangold.

Additional information

Received 9 December 2005; received after revision 13 April 2006; accepted 1 June 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mangold, U. Antizyme inhibitor: mysterious modulator of cell proliferation. Cell. Mol. Life Sci. 63, 2095–2101 (2006).

Download citation

  • Published:

  • Issue Date:

  • DOI: