Skip to main content


Log in

Endothelin-like peptides

  • Review
  • Published:
Cellular and Molecular Life Sciences CMLS Aims and scope Submit manuscript


Mammalian endothelins (ETs) and snake venom sarafotoxins (SRTXs) comprise structurally and functionally related potent vasoconstrictor isopeptides that act on the vascular system via identical receptors. This similarity is remarkable, since SRTXs are highly toxic components isolated from the venoms of snakes of the genus Atractaspis of the Atractaspididae family, while ETs are endogenous hormones of the mammalian vascular system. Since the first functional and structural description of SRTXs in 1988, the full extent of their natural diversity has become increasingly apparent, and this has led to the characterization of new families of endothelin-like peptides. Based on a combination of conventional biochemical approaches and the latest molecular biology and mass spectrometry techniques, this review describes the more recent panel of SRTX isopeptides isolated from various snake species within the Atractaspididae family, but also the similarities and differences that exist between sarafotoxins and endothelins in terms of their metabolism, genetic origin, structure and functional sites.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations


Corresponding author

Correspondence to F. Ducancel.

Additional information

Received 27 June 2005; received after revision 29 July 2005; accepted 2 September 2005

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ducancel, F. Endothelin-like peptides. Cell. Mol. Life Sci. 62, 2828–2839 (2005).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Key words.