Abstract.
Cytotoxic (CD8+) and helper (CD4+) T cells play a crucial role in resolving infections by intracellular pathogens. The development of technologies to visualize antigen-specific T cell responses in mice and men over the past decade has allowed a dissection of the formation of adaptive T cell immunity. This review gives a brief overview of the currently used detection techniques and possible future additions. Furthermore, we discuss our current understanding of the formation of antigen-specific T cell responses, with particular attention to the similarities and differences in CD4+ and CD8+ T cell responses, the functional heterogeneity within responder T cell pools and the regulation of CD8+ T cell responses by dendritic cells and CD4+ helper T cells.
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Received 16 June 2005; received after revision 2 August 2005; accepted 15 August 2005
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Schepers, K., Arens, R. & Schumacher, T.N.M. Dissection of cytotoxic and helper T cell responses. Cell. Mol. Life Sci. 62, 2695–2710 (2005). https://doi.org/10.1007/s00018-005-5266-1
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DOI: https://doi.org/10.1007/s00018-005-5266-1