Abstract.
The discovery that pyridoxamine (PM) can inhibit glycation reactions and the formation of advanced glycation end products (AGEs) stimulated new interest in this B6 vitamer as a prospective pharmacological agent for treatment of complications of diabetes. The mechanism of action of PM includes: (i) inhibition of AGE formation by blocking oxidative degradation of the Amadori intermediate of the Maillard reaction; (ii) scavenging of toxic carbonyl products of glucose and lipid degradation; and (iii) trapping of reactive oxygen species. The combination of these multiple activities along with PM safety posture it as a promising drug candidate for treatment of diabetic complications as well as other multifactorial chronic conditions in which oxidative reactions and carbonyl compounds confer pathogenicity.
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Received 1 March 2005; received after revision 25 March 2005; accepted 31 March 2005
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Voziyan, P.A., Hudson, B.G. Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage. CMLS, Cell. Mol. Life Sci. 62, 1671–1681 (2005). https://doi.org/10.1007/s00018-005-5082-7
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DOI: https://doi.org/10.1007/s00018-005-5082-7