Regulation of food intake by oleoylethanolamide


Oleoylethanolamide (OEA), the naturally occurring amide of ethanolamine and oleic acid, is an endogenous lipid that modulates feeding, body weight and lipid metabolism by binding with high affinity to the ligand-activated transcription factor, peroxisome proliferator-activated receptor-alpha (PPAR-α). In the present article, we describe the biochemical pathways responsible for the initiation and termination of OEA signaling, and outline the pharmacological properties of this compound in relation to its ability to activate PPAR-α. Finally, we discuss the possible role of OEA as a peripheral satiety hormone.

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Correspondence to D. Piomelli.

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Received 8 November 2004; received after revision 7 December 2004; accepted 10 December 2004

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Lo Verme, J., Gaetani, S., Fu, J. et al. Regulation of food intake by oleoylethanolamide. CMLS, Cell. Mol. Life Sci. 62, 708 (2005).

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Key words.

  • Oleoylethanolamide
  • palmitoylethanolamide
  • peroxisome proliferator-activated receptor-alpha (PPAR-α)
  • lipid
  • feeding
  • satiety
  • energy balance
  • metabolism