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The role of insulin and IGF-1 signaling in longevity

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There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

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Correspondence to C. R. Kahn.

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Received 8 July 2004; received after revision 25 August 2004; accepted 17 September 2004

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Katic, M., Kahn, C.R. The role of insulin and IGF-1 signaling in longevity. CMLS, Cell. Mol. Life Sci. 62, 320–343 (2005).

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