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Retention of atherogenic lipoproteins in atherogenesis

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Abstract

Atherosclerosis is a multifactorial disease whose pathogenesis is still unclear. Mounting evidence, however, supports the concept that subendothelial retention of apoB100-containing lipoproteins is the initiating event in atherogenesis. Subsequently, a series of biological responses to this retained material leads to specific molecular and cellular processes that promote lesion formation.

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Authors and Affiliations

  1. Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Göteborg University, 413 45, Göteborg, Sweden

    M. Gustafsson, C. Flood, P. Jirholt & J. Borén

Authors
  1. M. Gustafsson
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  2. C. Flood
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  3. P. Jirholt
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  4. J. Borén
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Corresponding author

Correspondence to J. Borén.

Additional information

Received 3 July 2003; received after revision 13 August 2003; accepted 15 August 2003

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Gustafsson, M., Flood, C., Jirholt, P. et al. Retention of atherogenic lipoproteins in atherogenesis. CMLS, Cell. Mol. Life Sci. 61, 4–9 (2004). https://doi.org/10.1007/s00018-003-3262-x

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  • DOI: https://doi.org/10.1007/s00018-003-3262-x

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