Skip to main content
Log in

Protecting the terminus: t-loops and telomere end-binding proteins

  • Multi-author Review
  • Published:
Cellular and Molecular Life Sciences CMLS Aims and scope Submit manuscript

Abstract

Telomeric DNA is composed of a region of duplex telomeric tract followed by a single-strand overhang on the 3′ G-rich strand. The DNA is packaged by proteins that associate directly with the single- and double-strand regions of the telomeric tract and by their associated proteins. This review discusses the evidence that G-strand overhangs are present on both ends of eukaryotic chromosomes and the steps needed to generate these overhangs. The overhangs are protected by specialized G-overhang-binding protein and/or invasion by the overhang of the duplex region of the telomeric tract to form a structure called a ‘t-loop’. The G-overhang-binding proteins identified from different species are described, and their properties compared. The data supporting the existence of t-loops at native telomeres is discussed, and the conditions required to promote their in vitro formation are presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. Price.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wei, C., Price, M. Protecting the terminus: t-loops and telomere end-binding proteins. CMLS, Cell. Mol. Life Sci. 60, 2283–2294 (2003). https://doi.org/10.1007/s00018-003-3244-z

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-003-3244-z

Navigation