Skip to main content

Advertisement

SpringerLink
Log in

Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer

  • Research Article
  • Published:
Cellular and Molecular Life Sciences CMLS Aims and scope Submit manuscript

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve diagnosis and treatment, key mechanisms of deregulated molecular functions have to be identified. Using microarray analysis, the expression patterns of 5600 human genes were assessed in PDAC by comparison with the normal pancreas and chronic pancreatitis (CP). The expression of 467 of 5600 genes was increased in PDAC in comparison to the normal pancreas, and the expression of 120 of these genes was not increased in CP. In addition, 341 of 5600 genes were expressed at decreased levels in PDAC tissues, of which 96 were decreased in comparison to both normal and CP tissues. Thus, a total of 808 of 5600 human genes were differentially expressed in pancreatic cancer. The identification of a large panel of altered genes in PDAC will stimulate additional studies that will lead to improved understanding of the molecular mechanisms underlying pancreatic malignant growth.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg (Germany), Fax + 49 6221 566903, e-mail: helmut_friess@med.uni-heidelberg.de , , , , , , DE

    H. Friess, J. Kleeff, L. Fenkell, A. Guweidhi & M. W. Büchler

  2. Section of Bioinformatics, Genetics, and Genomics, Hoffmann-La Roche Inc., Nutley, New Jersey (USA), , , , , , US

    J. Ding, J. A. Rosinski, J. F. Reidhaar-Olson & J. Hammer

  3. Departments of Medicine, Biological Chemistry and Pharmacology, University of California, Irvine, California (USA), , , , , , CA

    M. Korc

Authors
  1. H. Friess
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Kleeff
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Fenkell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. A. Rosinski
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Guweidhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. F. Reidhaar-Olson
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M. Korc
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. J. Hammer
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. W. Büchler
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received 28 January 2003; received after revision 9 March 2003; accepted 21 March 2003

RID="*"

ID="*"Corresponding author.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Friess, H., Ding, J., Kleeff, J. et al. Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer. CMLS, Cell. Mol. Life Sci. 60, 1180–1199 (2003). https://doi.org/10.1007/s00018-003-3036-5

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-003-3036-5

Search

Navigation