Skip to main content
SpringerLink
Log in

Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats

  • Research Article
  • Published:
Cellular and Molecular Life Sciences CMLS Aims and scope Submit manuscript

Abstract:

This study examined the changes occurring in the pattern of distribution and expression of neuronal nitric oxide synthase (nNOS)-positive nerves in the gastroduodenal tract of streptozotocin-induced diabetic rats. The ganglion cells of the myenteric plexus of the gastric antrum of normal rats contain nNOS. We also observed nNOS-positive neurons and fibres in the myenteric plexus of the duodenum of normal rats. After the onset of diabetes, the number and intensity of staining of nNOS-positive nerve profiles in the gastric antrum and duodenum did not change significantly. However, Western blotting showed a significant increase in the expression of nNOS after the onset of diabetes. In conclusion, diabetes of 4 and 32 weeks duration induced an increase in the tissue content of nNOS in the gastroduodenum of rat. The increase in the level of nNOS in the gastroduodenum of diabetic rats may explain why impaired gastric emptying is common in patients with diabetes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Human Anatomy, Faculty of Medicine & Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates), Fax: +971-3-7672033, e-mail: eadeghate@uaeu.ac.ae , , , , , , AE

    E. Adeghate & A. S. Ponery

  2. Department of Medical Microbiology, Faculty of Medicine & Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates), , , , , , AE

    B. al-Ramadi

  3. Department of Biochemistry, Faculty of Medicine & Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates), , , , , , AE

    A. M. Saleh & C. Vijayarasathy

  4. Department of Physiology, Faculty of Medicine & Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates), , , , , , AE

    K. Arafat, F. C. Howarth & T. El-Sharkawy

Authors
  1. E. Adeghate
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. al-Ramadi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. M. Saleh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Vijayarasathy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. S. Ponery
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Arafat
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F. C. Howarth
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. T. El-Sharkawy
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received 29 October 2002; received after revision 20 February 2003; accepted 20 March 2003

RID="*"

ID="*"Corresponding author.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Adeghate, E., al-Ramadi, B., Saleh, A. et al. Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats. CMLS, Cell. Mol. Life Sci. 60, 1172–1179 (2003). https://doi.org/10.1007/s00018-003-2298-2

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-003-2298-2

Search

Navigation