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Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease

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Abstract

Janus kinase/signal transduction and transcriptional activator (JAK/STAT) signaling pathway is a transport hub for cytokine secretion and exerts its effects. The activation of JAK/STAT signaling pathway is essential for the regulation of inflammatory responses. Inappropriate activation or deletion of JAK/STAT signaling pathway is the initiator of the inflammatory response. JAK/STAT signaling pathway has been demonstrated to be involved in the process of innate and adaptive immune response to inflammatory bowel disease (IBD). In this review, we discuss the role of the JAK/STAT signaling pathway in the regulation of different cells in IBD, as well as new findings on the involvement of the JAK/STAT signaling pathway in the regulation of the intestinal immune response. The current status of JAK inhibitors in the treatment of IBD is summarized as well. This review highlights natural remedies that can serve as potential JAK inhibitors. These phytochemicals may be useful in the identification of precursor compounds in the process of designing and developing novel JAK inhibitors.

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Acknowledgements

We would like to acknowledge the contributions of colleagues, institutions, or agencies that aided the efforts of the authors.

Funding

This work was supported by the National Key Research and Development Project of China (2017YFD050160203), National Natural Science Foundation of China (81600440).

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Author notes

  1. Liang Wang, Yan Hu, Baohui Song had equal contributions to this work.

Authors and Affiliations

  1. Research and Teaching Department of Comparative Medicine, Dalian Medical University, Dalian, 116044, China

    Liang Wang, Yan Hu, Baohui Song & Dapeng Chen

  2. Central Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China

    Yongjian Xiong

  3. Laboratory Animal Center, Dalian Medical University, Dalian, 116044, China

    Jingyu Wang

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  1. Liang Wang
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  2. Yan Hu
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  3. Baohui Song
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  4. Yongjian Xiong
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Contributions

All authors contributed to the study conception and design. The literature search and data analysis were performed by LW, YH, BS. The draft of the manuscript was written by LW, YH, BS. YX, JW, DC critically revised the work. All authors read and approved the final manuscript.

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Correspondence to Yongjian Xiong, Jingyu Wang or Dapeng Chen.

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Wang, L., Hu, Y., Song, B. et al. Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease. Inflamm. Res. 70, 753–764 (2021). https://doi.org/10.1007/s00011-021-01482-x

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