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Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice

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Abstract

Objective

Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.

Methods

The histamine production from Th2 cells was measured by EIA. The mRNA expression of histidine decarboxylase (HDC) was measured by real-time PCR. To investigate the roles of Th2 cell-derived histamine in vivo, we analyzed an antigen-specific Th2 cell transfer mouse model.

Results

Th2 cells produced histamine by T cell receptor stimulation, and these properties were specific for Th2 cells, but not Th1 cells and naïve CD4 T cells. The histamine produced from Th2 cells was involved in the infiltrations of Th2 cells in response to antigen exposure.

Conclusion

These results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders.

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References

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Acknowledgements

This work was supported by a Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Young Scientists (Grant Number 19K17912) to N.I. and a GlaxoSmithKline Japan Research Grant 2017 to N.I.

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Authors and Affiliations

  1. Department of Pathobiochemistry, Graduate School of Medicine, Osaka City University, Osaka, Japan

    Naruhito Iwasaki, Seigo Terawaki, Kouhei Shimizu, Daisuke Oikawa & Fuminori Tokunaga

  2. Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan

    Naruhito Iwasaki, Hirokazu Sakamoto & Kishiko Sunami

Authors
  1. Naruhito Iwasaki
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  2. Seigo Terawaki
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  3. Kouhei Shimizu
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  4. Daisuke Oikawa
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  5. Hirokazu Sakamoto
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  6. Kishiko Sunami
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  7. Fuminori Tokunaga
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Corresponding author

Correspondence to Naruhito Iwasaki.

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Responsible Editor: John DI Battista.

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Iwasaki, N., Terawaki, S., Shimizu, K. et al. Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. Inflamm. Res. 70, 539–541 (2021). https://doi.org/10.1007/s00011-021-01458-x

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  • DOI: https://doi.org/10.1007/s00011-021-01458-x

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