Shankar-Hari M, et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis ans septic shock (sepsis-3). JAMA. 2016;315:775–87.
Sartelli M, et al. Raising concerns about the sepsis-3 definitions. World J Emerg Surg. 2018;13:6.
Hotchkiss RS, et al. Sepsis and septic shock. Nat Rev Dis Primers. 2016;2:16045.
Angus DC, Van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369:840–51.
Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13:862–74.
Delano MJ, Ward PA. Sepsis-induced immune dysfunction: can immune therapies reduce mortality? J Clin Invest. 2016;126:23–31.
Cohen J, et al. Sepsis: a roadmap for future research. Lancet Infect Dis. 2015;15:581–614.
Jensen IJ, Sjaastad FV, Griffith TS, Badovinac VP. Sepsis-induced T cell immunoparalysis: the ins and outs of impaired T cell immunity. J Immunol. 2018;200:1543–53.
Savelkoel J, Claushuis TAM, vanEngelen TSR, Scheres LJJ, Wiersinga WJ. Global impact of World Sepsis Day on digital awareness of sepsis: an evaluation using Google Trends. Crit Care. 2018;22:61.
Anthony JL, Timothy RB, Matthew RR. Biology and metabolism of sepsis: innate immunity, bioenergetics, and autophagy. Surg Infect. 2016;17:286–93.
Zhang L, Ai YH, Tsung A. Clinical application: restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis (review). Exp Ther Med. 2016;12:1159–67.
Sridhar S, Botbol Y, Macian F, Cuervo AM. Autophagy and disease: always two sides to a problem. J pathol. 2012;226:255–73.
Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368:651–62.
Chen YQ, Klionsky DJ. The regulation of autophagy–unanswered questions. J Cell Sci. 2011;124:161–70.
Watanabe E, et al. Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest. 2009;9:549–61.
Ho J, et al. Autophagy in sepsis: degradation into exhaustion? Autophagy. 2016;12:1073–82.
Chen G, Li Y, Wang W, Deng L. Bioactivity and pharmacological properties of α-mangostin from the mangosteen fruit: a review. Expert Opin Ther Pat. 2018;3:1–13.
Scolamiero G, Pazzini C, Bonafè F, Guarnieri C, Muscari C. Effects of α-mangostin on viability, growth and cohesion of multicellular spheroids derived from human breast cancer cell lines. Int J Med Sci. 2018;15:23–30.
Liu T, et al. Alpha-mangostin attenuates diabetic nephropathy in association with suppression of acid sphingomyelianse and endoplasmic reticulum stress. Biochem Biophys Res Commun. 2018;496:394–400.
Pan T, et al. Alpha-Mangostin suppresses interleukin-1β-induced apoptosis in rat chondrocytes by inhibiting the NF-κB signaling pathway and delays the progression of osteoarthritis in a rat model. Int Immunopharmacol. 2017;52:156–62.
Pimchan T, Maensiri D, Eumkeb G. Synergy and mechanism of action of α-mangostin and ceftazidime against ceftazidime-resistant Acinetobacter baumannii. Lett Appl Microbiol. 2017;65:285–91.
You BH, et al. α-Mangostin ameliorates dextran sulfate sodium-induced colitis through inhibition of NF-κB and MAPK pathways. Int Immunopharmacol. 2017;49:212–21.
Franceschelli S, et al. A novel biological role of α-mangostin in modulating inflammatory response through the activation of SIRT-1 signaling pathway. J Cell Physiol. 2016;231:2439–51.
Sivaranjani M, et al. In vitro activity of alpha-mangostin in killing and eradicating Staphylococcus epidermidis RP62A biofilms. Appl Microbiol Biotechnol. 2017;101:3349–59.
Chen ZL, et al. Transferrin-modified liposome promotes α-mangostin to penetrate the blood-brain barrier. Nanomedicine. 2016;12:421–30.
Catorce MN, et al. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. J Neuroimmunol. 2016;297:20–7.
Patil NK, Bohannon JK, Sherwood ER. Immunotherapy: a promising approach to reverse sepsis-induced immunosuppression. Pharmacol Res. 2016;111:688–702.
Yadav H, Cartin-Ceba R. Balance between hyperinflammation and immunosuppression in sepsis. Semin Respir Crit Care Med. 2016;37:42.
Fattahi F, Ward PA. Understanding immunosuppression after sepsis. Immunity. 2017;47:3.
Venet F, Rimmelé T, Monneret G. Management of sepsis-induced immunosuppression. Crit Care Clin. 2018;34:97.
Cavaillon JM, Adib-Conquy M. Monocytes/macrophages and sepsis. Crit Care Med. 2005;33(Suppl):S506–9.
Rabani R, et al. Mesenchymal stem cells enhance NOX2 dependent ROS production and bacterial killing in macrophages during sepsis. Eur Respir J. 2018;8:1702021.
Liu Y, et al. Scutellarin Suppresses NLRP3 inflammasome activation in macrophages and protects mice against bacterial sepsis. Front Pharmacol. 2018;8:975.
Xing L, et al. Role of M2 Macrophages in Sepsis-Induced Acute Kidney Injury. Shock. 2017;1:233–9.
Linch SN, Danielson ET, Kelly AM, Lee JJ, Gold JA. The effect of IL-5 on macrophages and PMNs in sepsis. Am J Resp Crit Care. 2009;179:A1024.
Lu XJ, et al. LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor. J Exp Med. 2013;210:5–13.
Wang Y, et al. Alpha- mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates beta-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation. Neuropharmacology. 2012;62:871–81.
Jin L, Batra S, Jeyaseelan S. Deletion of Nlrp3 augments survival during polymicrobial sepsis by decreasing autophagy and enhancing phagocytosis. J Immunol. 2017;198:1253–62.
Long H, Xu B, Luo Y, Luo K. Artemisinin protects mice against burn sepsis through inhibiting NLRP3 inflammasome activation. Am J Emerg Med. 2016;34:772–7.
Wu D, et al. Intermedin1-53 protects cardiac fibroblasts by inhibiting NLRP3 inflammasome activation during sepsis. Inflammation. 2018;41:505–14.
Ohsumi Y. Historical landmarks of autophagy research. Cell Res. 2014;24:9–23.
Virgin HW, Levine B. Autophagy genes in immunity. Nat Immunol. 2009;10:461–70.