IL-33 attenuates mortality by promoting IFN-γ production in sepsis
Objective and design
Sepsis remains a major clinical problem with high morbidity and mortality. Interleukin (IL)-33 is a recently described member of the IL-1 family that is widely expressed and functions as a new inflammatory mediator. IL-33 has been reported to protect sepsis, but the underlying mechanisms are not well-elucidated.
Materials and methods
We measured the interferon gamma (IFN-γ) production in septic mice after IL-33 treatment.
IL-33 treatment enhanced the IFN-γ level in blood and promoted mice’s survival, so the protective effects of IL-33 depend on IFN-γ. The IL-33 treatment also promoted both γδ T cells and NK cells in septic mice.
Our data showed that IL-33 attenuates mortality by promoting IFN-γ production in sepsis.
KeywordsIL-33 IFN-γ γδ T cells NK cells Sepsis
This work was supported by The Natural Science Fund of Zhejiang Province (LQ16H150001) and The Medical Science Research Foundation of Zhejiang Province (2016KYA112).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants and/or animals
All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
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