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A cyclic pathway of P2 × 7, bradykinin, and dopamine receptor activation induces a sustained articular hyperalgesia in the knee joint of rats

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Abstract

Objective

We investigated whether: (1) P2 × 7 receptor activation by its agonist (BzATP) induces articular hyperalgesia in the rat’s knee joint via inflammatory mechanisms and (2) activation of P2 × 7 receptors by endogenous ATP contributes to the articular hyperalgesia induced by bradykinin, TNF-α, IL-1β, CINC-1, PGE2, and dopamine.

Methods

The articular hyperalgesia was quantified using the rat knee joint incapacitation test. The knee joint inflammation, characterized by the concentration of pro-inflammatory cytokines and by neutrophil migration, was quantified in the synovial lavage fluid by ELISA and myeloperoxidase enzyme activity assay, respectively.

Results

BzATP induced a dose-dependent articular hyperalgesia in the rat’s knee joint that was significantly reduced by the selective antagonists for P2 × 7, bradykinin B1 or B2 receptors, β1 or β2 adrenoceptors, and by pre-treatment with Indomethacin. BzATP induced a local increase of TNF-α, IL-1β, IL-6, and CINC-1 concentration and neutrophil migration into the knee joint. The co-administration of the selective P2 × 7 receptor antagonist A-740003 significantly reduced the articular hyperalgesia induced by bradykinin and dopamine, but not by TNF-α, IL-1β, CINC-1, and PGE2.

Conclusions

P2 × 7 receptor activation induces articular hyperalgesia mediated by the previous inflammatory mediator release. P2 × 7 receptor-induced articular hyperalgesia is sustained by the involvement of this purinergic receptor in bradykinin and dopamine-induced hyperalgesia in the knee joint.

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Acknowledgements

This work was supported by Grants from São Paulo Research Foundation—FAPESP, Brazil (2009/16854-3 and 2010/05381-4).

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Authors and Affiliations

  1. Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, UNICAMP, Rua Monteiro Lobato, 255, Campinas, SP, CEP 13083-862, Brazil

    Juliana Maia Teixeira, Carlos Amílcar Parada & Cláudia Herrera Tambeli

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  1. Juliana Maia Teixeira
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  2. Carlos Amílcar Parada
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  3. Cláudia Herrera Tambeli
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Correspondence to Cláudia Herrera Tambeli.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study involving animals were in accordance with the ethical standards of the Committee on Animal Research of the University of Campinas and were conformed to IASP guidelines for the study of the pain in animals.

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Communicated by John Di Battista.

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Teixeira, J.M., Parada, C.A. & Tambeli, C.H. A cyclic pathway of P2 × 7, bradykinin, and dopamine receptor activation induces a sustained articular hyperalgesia in the knee joint of rats. Inflamm. Res. 67, 301–314 (2018). https://doi.org/10.1007/s00011-017-1122-7

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  • DOI: https://doi.org/10.1007/s00011-017-1122-7

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