Glycated albumin (GA) and inflammation: role of GA as a potential marker of inflammation

Abstract

Aims

Abnormal levels of glycated albumin (GA) are associated with the onset of both diabetes and inflammation. Although inflammation has long been associated with diabetes, this article aims to explore the underlying mechanisms of this relationship as it pertains to the role of GA.

Methods

We have reviewed 52 research articles since the year 2000. Common search terms used were “(inflammatory mediator) and GA” or “inflammation and GA”. The findings have been organized according to diabetic complications with respect to the interactions of GA and inflammatory mediators. Glycated albumin and specific inflammatory mediators have been reported to play various roles in the pathogenesis of insulin resistance, atherosclerosis, coronary artery disease, retinopathy, and nephropathy. In the case of nephropathy and recently retinopathy, there is considerable evidence for GA in concert with inflammation playing a direct role in organ pathology. There is copious literature detailing GA’s involvement in stimulating inflammatory markers and certain pro-inflammatory cytokines. A recent clinical study has shown GA to be a marker for inflammation in non-diabetic rheumatoid arthritis patients with the significance of standard inflammatory markers.

Conclusions

The clinical utility of GA measurement may likely reside in its versatility as both a mediator of inflammation as well as a marker to track hyperglycemia and other diabetes complications. Further understanding of the role GA plays in glycemic and inflammatory diseases could lead to its acceptance as an independent bio-inflammatory marker.

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Acknowledgements

Dr. David Horwitz, Dr. Tessa Lebinger, Dr. Omar Ali, Dr. Salim Aziz, Dr. Saul Ship, and Dr. Alan Carter of the Epinex Diagnostics Inc. Science Advisory Board; Dr. David Trasoff, Tasnim Ahmed, and Kajal Bains of Epinex Diagnostics Inc.

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Correspondence to Dimple Patel.

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Responsible Editor: Artur Bauhofer.

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Roohk, H.V., Zaidi, A.R. & Patel, D. Glycated albumin (GA) and inflammation: role of GA as a potential marker of inflammation. Inflamm. Res. 67, 21–30 (2018). https://doi.org/10.1007/s00011-017-1089-4

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Keywords

  • Inflammation
  • Glycated albumin
  • Inflammatory marker
  • Glycated albumin point-of-care test