Skip to main content
Log in

Complement C3a levels and misinterpretation of classifier technology

  • Letter to the Editor
  • Published:
Inflammation Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Széplaki G, Boros AM, Szilágyi S, Osztheimer I, Jenei Z, Kosztin A, et al. Complement C3a predicts outcome in cardiac resynchronization therapy of heart failure. Inflamm Res. 2016;65(12):933–40. doi:10.1007/s00011-016-0976-4.

    Article  PubMed  Google Scholar 

  2. Steyerberg EW, Vickers AJ, Cook NR, Gerds T, Gonen M, Obuchowski N, et al. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology (Cambridge, Mass). 2010;21(1):128–38. doi:10.1097/EDE.0b013e3181c30fb2.

    Article  Google Scholar 

  3. Leening MJ, Vedder MM, Witteman JC, Pencina MJ, Steyerberg EW. Net reclassification improvement: computation, interpretation, and controversies: a literature review and clinician’s guide. Ann Intern Med. 2014;160(2):122–31. doi:10.7326/M13-1522.

    Article  PubMed  Google Scholar 

  4. Petretta M, Cuocolo A. Prediction models for risk classification in cardiovascular disease. Eur J Nucl Med Mol Imaging. 2012;39(12):1959–69. doi:10.1007/s00259-012-2254-1.

    Article  PubMed  Google Scholar 

  5. Hilden J, Gerds TA. A note on the evaluation of novel biomarkers: do not rely on integrated discrimination improvement and net reclassification index. Stat Med. 2014;33(19):3405–14. doi:10.1002/sim.5804.

    Article  PubMed  Google Scholar 

  6. Leening MJ, Steyerberg EW, Van Calster B, D’Agostino RB Sr, Pencina MJ. Net reclassification improvement and integrated discrimination improvement require calibrated models: relevance from a marker and model perspective. Stat Med. 2014;33(19):3415–8. doi:10.1002/sim.6133.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mario Petretta.

Additional information

Responsible Editor: Andrew Roberts.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Petretta, M. Complement C3a levels and misinterpretation of classifier technology. Inflamm. Res. 66, 281–282 (2017). https://doi.org/10.1007/s00011-016-1016-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00011-016-1016-0

Keywords

Navigation