Abstract
Objective
Considering that asthma might have their onset in the intrauterine life and the exposure to FA during pregnancy interferes in the immune system of offspring, here we hypothesized that high dose of FA exposure during pregnancy could to contribute for development and severity of asthma in the offspring.
Methods
Pregnant Wistar rats were submitted to FA inhalation (6.13 mg/m3, 1 h/day, 5 days/week, for 21 days) or vehicle (distillated water). After 30 days of birth, the offspring was sensitized with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1 %, 15 min, 3 days). After 24 h the OVA challenge, the analyses were performed. Non-manipulated rats were used as basal parameters.
Results
Our data show that the exposure to high dose of FA during pregnancy predisposes the development of neutrophilic lung inflammation in the offspring, as observed by the profile of cells and cytokines in the lung.
Conclusion
This study contributes to the understanding of effects of pollution on the development of lung diseases.
This is a preview of subscription content, log in via an institution to check access.
References
Klein RC, King C, Castagna P. Controlling formaldehyde exposure in an academic gross anatomy laboratory. J Occup Environ Hyg. 2014;11(3):127–32.
Maiellaro M, Correa-Costa M, Vitoretti LB, Gimenes-Junior JA, Câmara NOS, De Lima WT, Farsky SHP, Lino-dos-Santos-Franco A. Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring. Toxicol Appl Pharmacol. 2014;278(3):266–74.
Silva Ibrahim B, Miranda da Silva C, Barioni ÉD, Correa-Costa M, Drewes CC, Saraiva Câmara NO, Tavares-de-Lima W, Poliselli Farsky SH, Lino-dos-Santos-Franco A. Formaldehyde inhalation during pregnancy abolishes the development of acute innate inflammation in offspring. Toxicol Lett. 2015;235(2):147–54.
Manners S, Alam R, Schwartz DA, Gorska MM. A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust. J Allergy Clin Immunol. 2014;134:63–72.
Yoshida S, Takano H, Nishikawa M, Miao H, Ichinose T. Effects of fetal exposureto urban particulate matter on the immune system of male mouse offspring. Biol Pharm Bull. 2012;35:1238–43.
Pelaia G, Vatrella A, Busceti MT, Gallelli L, Calabrese C, Terracciano R, Maselli R. Cellular mechanisms underlying eosinophilic and neutrophilic airway inflammation in asthma. Mediat inflamm. 2015:879783. Epub 2015 Mar 23
Wang YH, Voo SK, Liu B, Chen CY, Uygunglil B, Spoede W, Bernsetin JA, Huston DP, Liu Y. A novel subset of CD4 Th2 memory/effector cells that produce inflammatory IL-17 cytokine and promote exacerbation of chronic allergic asthma. J Exp Med. 2010;207(11):2479–91.
Pichavant M, Goya S, Meyer EH, Jonston RA, Kim HY, Matangkasombut P, Zhu M, Iwakura Y, Savage PB, DeKruff RH, Shore SA, Umetsu DT. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med. 2008;205(2): 385–93
Collins PD, Marleau S, GriffithsJohnson DA, Jose PJ, Williams TJ. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med. 1995;182(4):1169–74.
Acknowledgments
This study was sponsored by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP: 2011/51711-9). Marília Maiellaro is a scholarship holder from FAPESP (2013/08796-9).
Author information
Authors and Affiliations
Corresponding author
Additional information
Responsible Editor: John Di Battista.
Rights and permissions
About this article
Cite this article
Maiellaro, M., Macedo, R.S., Mendes, E. et al. High dose of formaldehyde exposure during pregnancy increases neutrophils lung influx evoked by ovalbumin in the offspring. Inflamm. Res. 65, 179–181 (2016). https://doi.org/10.1007/s00011-015-0901-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00011-015-0901-2