Inflammation Research

, Volume 62, Issue 5, pp 441–450 | Cite as

Historical overview of studies on inflammation in Russia

  • Liudmila Buryachkovskaya
  • Alexander Sumarokov
  • Nikita Lomakin
History of inflammation



Historical overview of development investigations on inflammation in Russia up to date is presented.

Material and methods

Analysis of modern Russian language literature (1950–2010) on history of medicine and researchers’ activity on inflammation, as well as Russian language content of internet on this theme, was made. Many names of Russian researchers are still little known to the English-speaking Western readers.


Starting in the eighteenth century, the mystery of the inner workings of the inflammation process attracted the interest of physicians and biologists of the Russian Empire. Accumulated knowledge focused mainly on the etiological factors of inflammation. In the nineteenth century, scientific schools emerged for studying inflammation and established close contacts with leading scientists in other countries. At this time, Ilya Mechnikov formulated his famous biological theory of inflammation, according to which inflammation is a protective adaptation response to an injury. He also developed his teaching on phagocytosis and was awarded the Nobel Prize. In the twentieth century, Russian scientists participated in the discovery of viruses and new bacterial pathogens, and in the investigation of the mechanics of the genesis and development of inflammatory processes.


Today interest in studies of inflammation in Russia is on the increase; scientists united by the Russian Inflammation Society continue their quest to investigate inflammatory mediators, and study molecular and cellular mechanisms and approaches in the treatment of complications associated with inflammation.


Inflammation Russian scientist History Invention 



This work was supported by the Russian Inflammation Society. We thank Prof. Strukova for presenting information on some studies included in the paper. We thank the relatives of Prof. Zalessky for submitted materials regarding his studies on inflammation.


  1. 1.
    Samoylovich D. Speculation about St. Sebastians disease in 1771 in Russian empire especially in Moscow, Selected works, Moscow 1952; 2, 8–278 (in Russian).Google Scholar
  2. 2.
    Pirogov Readings 1954. Medgiz, 1956. p. 17 (in Russian).Google Scholar
  3. 3.
    Polunin AI. Abhandlung über die Cholera. Diss M. Leipz., 1849 (in German).Google Scholar
  4. 4.
    Polunin AI. Remarks about inflammation. Moscow Medical Journal, 1852; II:181(in Russian).Google Scholar
  5. 5.
    Pashutin V. Course of general and experimental pathology. Special Collections Research Center University of Chicago Library. 1908. p. 1010 (in English).Google Scholar
  6. 6.
    Foht AB. Inflammation of pericardial sac. Moscow. 1899 (in Russian).Google Scholar
  7. 7.
    Sakharov G. Metodologiia patologii, 2nd ed. Moscow, 1935 (in Russian).Google Scholar
  8. 8.
    Podvisotsky VV. Fundamentals of general pathology. Saint-Petersburg, 1894 (in Russian).Google Scholar
  9. 9.
    Mechnikov I. On the present state of the question of immunity in infectious diseases. Nobel Lectures in Physiology or Medicine 1901–1921. 1967 Amsterdam, Elsevier Publishing Company (in English).Google Scholar
  10. 10.
    Ivanovsky, D. 1892 Ueber die Mosaikkrankheit der Tabakspflanze. St Petersb. Acad. Imp. Sci. Bull. 35, 67–70. [id. Beih. Bot. Centralbl. 3(1893), 266–268. English translation published in 1942: concerning the mosaic disease of tobacco. Phytopathol. Classics 7, 25–30 (in English).Google Scholar
  11. 11.
    Maximow AA, Bloom W. A textbook of histology. Philadelphia: WB Saunders company; 1938. (in English).Google Scholar
  12. 12.
    Anichkov NN. Experimental arteriosclerosis in animals. In: Cowdry EV, editor. Arteriosclerosis: A survey of the problem. New York: MacMillan Publishing; 1933. p. 271–322 (in English).Google Scholar
  13. 13.
    Anitschkow N, Chalatow S. Ueber experimentelle Cholester-insteatose und ihre Bedeutung fuer die Entstehung einiger pathologischer Prozesse. Zentrbl Allg Pathol Pathol Anat 1913;24:1–9 (in German).Google Scholar
  14. 14.
    Gamaleya NF. About immunity. Materials of Russian Doctors Society in Odessa. 1899, Vol. 1, p. 37–42 (in Russian).Google Scholar
  15. 15.
    Talalaev V. Acute rheumatism (pathogeny, pathological anatomy, and clinical anatomical classification). Moscow. 1929. (in Russian).Google Scholar
  16. 16.
    Zalessky GD. Rheumatism and capillary penetrance. Novosibirsk, 1949 (in Russian).Google Scholar
  17. 17.
    Zalessky GD. Role of the P-virus in etiology and pathogenesis of rheumatic disease. NGMI, Novosibirsk, 1966, Vol. XLVII, p. 13.Google Scholar
  18. 18.
    Abrikosov AI. Fundamentals of pathoanatomy, Moscow, 1933 (in Russian).Google Scholar
  19. 19.
    Davidovsky IV. Inflammation: state-of-the-art. Moscow Med. J., 1924; 5 (in Russian).Google Scholar
  20. 20.
    Strukov AI. Pathoanatomy, second edition, Medicina, 1971 (in Russian).Google Scholar
  21. 21.
    Klimov AN. Immunoreactivity and atherosclerosis. 1986, Medicina, p. 191 (in Russian).Google Scholar
  22. 22.
    Nagornev VA, Pigarevskiĭ PV, Mal’tseva SV. Chaperones and their role in atherogenesis. Vestn Ross Akad Med Nauk. 2008;(1):41–45 (in Russian).Google Scholar
  23. 23.
    Serov VV, Paukov VS. Inflammation: Guidelines for practitioners. Medicina, 1995. p. 640 (in Russian).Google Scholar
  24. 24.
    Freydlin IS. Regulatory cells: etiology and function. Med. Immunol. 2005; 7(4):347–354 (in Russian).Google Scholar
  25. 25.
    Nazarov PG, Pronina AP, Trulev AS, Puzireva VP, Popov VG. Pentraxins in defense reaction and immunoregulation processes. Med. Immunol. 2009;4(5):326 (in Russian).Google Scholar
  26. 26.
    Kozlov VA. Gomeostatic proliferation of lymphocytes in terms of immunopathogenesis of different diseases. Immunology. 2006;27(6):378–382 (in Russian).Google Scholar
  27. 27.
    Strukova S. Blood coagulation-dependent inflammation. Coagulation-dependent inflammation and inflammation-dependent thrombosis. Front Biosci. 2006;11:59–80.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Liudmila Buryachkovskaya
    • 1
  • Alexander Sumarokov
    • 2
  • Nikita Lomakin
    • 3
  1. 1.Institute of Experimental CardiologyCardiology Research ComplexMoscowRussia
  2. 2.Institute of Clinical CardiologyCardiology Research ComplexMoscowRussia
  3. 3.Head of the Intensive Cardiology DepartmentCentral Clinical Hospital of the Presidential Department of Russian FederationMoscowRussia

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